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DRUGS:  TAC

Thiazolidine-4-Carboxylic Acid


 

The Cure for Cancer? 

COPYRIGHT (C) 1999 by JOHN S. ROBERTS

This report is 30 pages long.

SHOULD JOHN STACY ROBERTS BE AWARDED A NOBEL PRIZE IN MEDICINE FOR HIS RESEARCH INTO CANCER, HIV/AIDS AND ALCOHOL ABUSE?

thiazolidine-4-carboxylic acid also known as 'Tac'

In this decade Professor Andrew Victor Schally, a Nobel Laureate, and his colleagues have been exploring the anti-cancer possibilities of compounds which include this acid in their composition.

Thus far they have achieved very encouraging anti-cancer results in the laboratory - "...the activity of 2-pyrrolino-DOX and its conjugates was 2500 times higher than..."

Refer to: (The emphasis is mine, John S. Roberts.)

"Potent bombesin antagonists with C-terminal Leu-psi(CH2-N)-Tac-NH2 or its derivatives", 'Proceedings of the National Academy of Sciences of the United States of America', Vol. 91, pp.12664-12668, December, 1994.

"Design, synthesis, and 'in vitro' evaluation of cytotoxic analogs of bombesin-like peptides containing doxorubicin or its intensely potent derivative, 2-pyrrolinodoxorubicin", 'Proceedings of the National Academy of Sciences of the United States of America', Vol. 94, pp. 652-656, January, 1997.

This acid has other names: '4-Thiazolidine-carboxylic acid', 'Timonacic' and 'Thioproline'; Professor Schally and his colleagues, R.-Z. Cai, H. Reile and P. Armatis refer to it as 'thiazolidine-4-carboxylic acid' and abbreviate it 'Tac'; its molecular mass is 133.18.

Professor Schally and his colleagues are associated with the Endocrine, Polypeptide and Cancer Institute, Veterans Affairs Medical Center, New Orleans, Louisiana. (When the December, 1994 article was published.)

An examination of the December, 1994 article reveals the following:

Tac is part of the peptide structure with the Code No. RC-3950-II.

The structure appears thusly - [D-Phe6,13psi14,CH2-N,Tac14]BN-(6-14) and has a retention time of 14.63.

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The formula for RC-3950-II is C51/H72/N14/O9/S1 and the Molecular mass is 1056.5.

The Receptor binding for RC-3950-II is 0.078 and the Antagonistic activity is 1.0

The abstract concludes: ".....The best BN antagonists of this series, RC-3950-II....., inhibited gastrin-releasing peptide-stimulated growth of Swiss 3T3 cells with IC50 values of 1 nM and 6 nM, respectively. Since antagonists of this class inhibit growth of various tumors in animal cancer models, some of them may have clinical applications."

The article concludes: "...Tac is a closed ring analog of Met and is more hydrophobic than Met. The replacement of Phe withTac in reduced bond BN antagonists produced improved Ki and IC50 values. BN antagonists such as RC-3950-II may have important therapeutic applications for the treatment of various malignancies such as prostatic, gastric, and pancreatic cancer, small cell lung carcinoma, and other tumors."

My fellow citizen, after you read the following pages you will see that 'Tac' by itself, and not in combination with any other chemicals, was used to cure people of cancer 20 years ago.

The molecular mass of Professor Schally's "best BN antagonist", RC-3950-II, is 1056.5; that of 'Tac' is 133.18; less is best!

It is my hope that Professor Schally, his colleagues and the scientific and medical community of the world will investigate this unique phenomenon - a possible, simple cure, for cancer.

'MedLine' is on 'The INTERNET'

'Medline' is published by the National Library of Medicine and contains over 9 million citations. On May, 4, 1999, there were 1,205,513 articles which mentioned the word 'cancer' at least one time. There were 2,216 articles which mentioned the word 'anti-cancer' at least one time. There were 2 articles in which the words 'anti-cancer' and 'thiazolidine-4-carboxylic acid' appear together; as you will see on the next page, this amount does not increase.

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JULY 28, 1999, compared to May 4, 1999 -

Number of citations containing the word, 'cancer' - 1,222,331- an increase of 16,818

Number of citations containing the word, 'anti-cancer' - 2280 - an increase of 64

Number of citations containing the words, 'anti-cancer' and 'thiazolidine-4-carboxylic acid' - 2.

My fellow citizen - THIS IS HOW YOU CAN SEE THE 2 CITATIONS -The following instructions are written with the assumption that you have never used a computer.

1. Look at the very first screen which appears after you have accessed 'The INTERNET'.

2. About one and a quarter inches from the top of the screen you will see a box labelled, 'Address'; on my screen it is about 9 inches long and one quarter of an inch high. Concentrate on this box.

3. Click into this box at anyplace on its 9 inch length. Click into it by moving the arrow of your 'mouse' inside it and pressing the left hand button of the mouse. When you do this a blue back ground appears in the 'Address' box. Let go of the mouse at this time.

4. Now, type into the 'Address' box the following (don't worry about making mistakes because you know you can correct them by simply pressing the 'Backspace' key of your keyboard):

www.ncbi.nlm.nih.gov/pubmed

and then press the 'Enter' button on your keyboard.

5. A screen will appear titled 'PubMed'.

6. Look underneath the words 'Search MEDLINE for', and you see an empty box about 4" long and one quarter inch high.

7. Click into this box with your arrow; a flashing line one quarter inch high appears at the far left corner of the box.

8. Type: thiazolidine-4-carboxylic acid anti-cancer

and don't worry about making a mistake; pressing on 'Backspace' on your keyboard will correct any mistake.

9. Click on to 'Search' with your arrow and a screen with this heading appears:

NCBI PubMed PubMed QUERY PubMed?

10. Move your arrow to the name, 'Smeyers', and click on to it with the left hand button of your mouse. You know you are properly 'clicked on' when a little hour glass appears. A passage appears which contains these words:

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'anti-cancer' and '4-thiazolidine-carboxylic acid'.

11. In the upper left hand corner of the screen near the very top there is a little arrow pointing left; it says, 'Back', underneath. Direct your mouse's arrow to it and click on with the left hand button of the mouse, and you will see that this gets you back to the previous screen.

12. Now, move your arrow to the name 'Lankelma' and click on; note that this passage concludes with the words:

"...thioproline as an anti-cancer agent."

Thioproline, 4-thiazolidine-carboxylic acid and thiazolidine-4-carboxylic acid are the same thing.

Thus you have seen the two citations. Is this acid the cure for cancer?

13. Let's see. Return again to the previous screen by clicking on to the left hand, 'Back', button at the upper top left of the screen.

14. Now look at the box, it's not quite 4", which appears under 'NCBI PubMed PubMedQUERY PubMed?'.

15. Erase "thiazolidine-4-carboxylic acid anti-cancer" by clicking on to 'clear', one inch to the right.

16. Click into the blank box (Remember, a flashing line one quarter inch high will appear at the left.) and type:

thioproline cancer brugarolas

Then click on to 'Search'.

Again, if the little hour glass appears you know you have done it correctly.

You can see that the screen shows two 'Brugarolas'. There is no abstract for the first 'Brugarolas'.

17. Click on to the bottom 'Brugarolas'; this passage contains an abstract; an abstract is a summary of a scientific article; this abstract contains 3 sentences; the abstract begins and ends thusly:

"Thiazolidine-4-carboxylic acid.....Histological studies showed involution and transformation into low-grade malignancies and disappearance of evidence of cancer."

To repeat: "...diappearance of evidence of cancer."

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The complete article is published in 'The Lancet', January, 12, 1980, pages, 68-70; the title is:

'Treatment of cancer by an inducer of reverse transformation'.

If you obtain this article, you will find that the following passages are contained therein: (my underline)

"No toxicity was observed and all regimens were equally well tolerated. Most patients had a feeling of well-being and there was no nausea, vomiting, myelo-depression, or central-nervous-system symptoms. No changes in pulmonary, cardiac, hepatic, or renal functions were found..." page 69

"Thioproline seemed to be completely nontoxic over a wide range of doses, and had considerable antitumour effect in epidermoid carcinoma of the head and neck. Definite signs of activity were observed in epidermoid carcinoma of other regions and in other solid tumours, such as breast, renal, ovary, thyroid, and parotid cancer. page 69

"Reverse transformation seemed to affect only tumour cells, since no effect was observed in the normal skin, mucosae, or other epithelial tissues. The selective character of this action explained the absence of toxicity of thioproline treatment." page 70

Further research revealed that this acid is a bit more toxic than the authors of this article initially thought, and because of this toxicity it has been impossible, in the past, to administer orally (by swallowing) 'mega-doses' of this acid. ('The Lancet' article cites that only 5 mg/kg. daily of the acid was administered orally.)

This acid is composed of harmless L-Cysteine (one half) and poisonous formaldehyde (one half).

The following sentences are some of the most significant in the history of medical science. As far as I can determine they do not appear in 'MedLine'. They are a just a small part of the epoch research of Dr. Herbert Sprince and his associates.

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This passage is found in 'Abstracts of 148th National Meeting of AAAS', January 3-8, 1982. Washington, D.C.,1982:151. 'L-ascorbic acid (LAA)' is vitamin C. The underlining was done by the authors.

"Protection against Formaldehyde Toxicity by L-Ascorbic Acid in Rats. H. Sprince, G.G. Smith, and D.A.Rinehimer (VA Med. Ctr., Coatesville, PA 19320; Depts. Psychiatry & Pharmacology, Jefferson Med. Coll., Phila., PA 19107.): Formaldehyde (FMA) is an important toxicant of cigarette smoke and currently the center of controversy as a potential human carcinogen. Previously, we reported partial protection in rats (55% survivors) by single (underline) oral doses of L-ascorbic acid (LAA) against lethal (LD95) doses of FMA. (Agents and Actions 9, 407, 1979). We now report additional findings pointing to LAA as a protectant against FMA. In acute toxicity tests with male rats (ca 103 days old, wt 420 gm), LAA in saline and saline controls were orally intubated 3 times within 24 hours (at 23.5, 5, 0.5 hrs.) prior to oral intubation of an LD 95 dose of FMA in saline (= 11.0 mmoles/kg). Protection measured as percent survivors (% S) after 72 hours was: 87% S for LAA at 3 mmoles/kg vs 7% S for saline controls. LAA protection was dose-related. In chronic toxicity tests with male rats (ca 102 days old, wt 420 gm), LAA and saline controls were orally intubated 1 hour prior to an oral LD 25 dose of FMA (= 5mmoles/kg) daily 5 days/week for 4 weeks. After 4 weeks, % S and mean body weights of survivors were respectively: 90% S and 416 gm for LAA at 3 mmoles/kg vs 40% S and 352 gm for saline controls and 100% S and 452 gm for untreated controls. Conclusions: Repeated high oral doses of L-ascorbic acid can protect rats appreciably against the toxicity and lethality of formaldehyde. The protective mechanism is as yet unknown. (Supp. by U. S. Admin.)"

THANKS TO Dr. SPRINCE AND HIS ASSOCIATES, I, John Stacy Roberts, have made a most fortuitous and felicitous discovery; it is one of the most significant medical discoveries of all time -

IN THE HUMAN BODY, VITAMIN C AFFORDS PROTECTION AGAINST THE DEADLY

TOXICITY OF FORMALDEHYDE.

In his conclusion Dr. Sprince stated, "Repeated high oral doses of L-ascorbic acid (Vitamin C) can protect rats appreciably against the toxicity and lethality of formaldehyde."

Soon I will cite two anecdotal cases which will demonstrate that human beings are equally well protected against the toxicity and lethality of formaldehyde by vitamin C. Soon I will describe a procedure. It is my hope that medical authorities will launch a clinical trial of this procedure.

If my words prove true, this discovery will allow a cancer patient to swallow MEGA-DOSES OF THIAZOLIDINE-4-CARBOXYLIC ACID.

This acid is chemically related to PENICILLIN.

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As far as I can determine, no one else in the history of science and medicine has realized that vitamin C might prove to be the golden key which could enable a cancer patient to unlock the full power of this acid within his or her body.

In a June 17, 1999 letter addressed to the Nobel Committee for Medicine in Stockholm, Sweden, my wife wrote:

"Dear Members of the Nobel Committee for Medicine, If a clinical trial proves that the words of my husband, John Stacy Roberts, are true relative to the manner in which solid cancerous tumors can be made to disappear from the human body, I, Margaret Vargas Roberts, think his name should be placed in nomination to receive a Nobel Prize in Medicine."

I, John S. Roberts, challenge the reader - go to any library and look in the index of every book about CANCER and I would be willing to bet that you won't find one reference to 'Thiazolidine-4-carboxylic acid'.

This acid is chemically simple to make; the following passage is from page 203 of Volume 59, January, 1937, 'American Chemical Society'. (See page 29 for a brief biography of Sarah Ratner.)

SARAH RATNER WROTE IT -

"Thiazolidine-4-carboxylic Acid. - The cysteine hydrochloride from 30 g. of cystine was dissolved in 100 cc. of water; 22 cc. of commercial 40% formaldehyde (1.1 mole) was added, and the mixture allowed to stand overnight at room temperature. On the addition of 25 cc. of pyridine, crystals soon separated. The whole was diluted with 50 cc. of alcohol and filtered. The product (28.2 g.) was recrystallized from hot water. The resulting long, colorless needles, which melt with decomposition at 196-197 degrees, are insoluble in alcohol, somewhat soluble in cold water, readily soluble in hot water, in acid and in alkali."

In my opinion, the following procedure might be effective toward curing cancer (I don't know about leukemia).

12 days of the procedure should be adequate to see if anti-cancer results are being obtained; 2 days will be devoted to preparation and 10 days will be devoted to the treatment.

Hopefully, experience will show that the phenomenal protection which vitamin C affords against formaldehyde's toxicity will enable the dosage amount to be increased beyond the 40 mg/kg. amount for adults and the 20 mg/kg. amount for children.

A PROCEDURE PROPOSED BY JOHN S. ROBERTS TO CURE CANCER (EXCEPTING LEUKEMIA) BY UTILIZING THIAZOLIDINE-4-CARBOXYLIC ACID & VITAMIN C & MAGNESIUM & ZINC & MANGANESE.

THE PROCEDURE DEMANDS THAT TWO DAYS BEFORE THE TREATMENT COMMENCES, THE PATIENT WILL HAVE SWALLOWED 10,000 mg. OF VITAMIN C EACH DAY. 10,000 mg. IS NOT TO BE SWALLOWED ALL AT ONCE, RATHER, ONE 1,000 mg. VITAMIN C TABLET WILL BE SWALLOWED EVERY HOUR UNTIL 10 ARE CONSUMED BY THE END OF THE DAY. REGULAR VITAMIN C TABLETS ARE TO BE USED, NOT TIMED RELEASE. THE TOTAL OF THE VITAMIN C SWALLOWED OVER TWO DAYS TIME WILL EQUAL 20,000 mg.

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IF THE PATIENT DOES NOT SWALLOW VITAMIN C IN THE MANNER I DESCRIBE, I, JOHN S. ROBERTS, AM NOT RESPONSIBLE IF ANY HARM BEFALLS THAT PATIENT BECAUSE OF A FORMALDEHYDE OVERDOSE.

FIRST, LET'S DETERMINE HOW MUCH ACID SHOULD BE SWALLOWED BY THE PATIENT; LET'S ASSUME THAT THE PATIENT IS A 150 lb. (68 kg.) ADULT.

THE MERCK INDEX STATES THIS ABOUT THE LETHAL DOSAGE (LD) AMOUNT FOR THIS ACID -

"LD 50 ORALLY IN MICE: 400 mg/kg."

THE MERCK INDEX STATES THIS ABOUT THE LETHAL DOSAGE (LD) AMOUNT FOR 'TYLENOL' -

"LD 50 IN MICE (mg/kg): 338 ORALLY..."

THE SMALLER THE NUMBER, THE MORE TOXIC THE SUBSTANCE.

TYLENOL IS MORE TOXIC THAN THIS ACID!

FOR ADULTS, LET'S START OUT BY ADMINISTERING 40 mg/kg. FOR CHILDREN, LET'S START OUT BY ADMINISTERING 20 mg/kg.

EVERYDAY A 150 lb. ADULT WOULD SWALLOW 2720 mg. (40 mg. x 68 kg. equals 2720 mg.) OF THE ACID. THIS WOULD NOT BE SWALLOWED ALL AT ONCE BUT WOULD BE SPACED OUT TO THREE SEPARATE OCCASIONS DURING THE DAY.

TO REPEAT, THE TREATMENT WILL ONLY BEGIN AFTER THE PATIENT HAS SWALLOWED A TOTAL OF 20,000 mg. OF VITAMIN C (NOT TIMED RELEASE).

THE 10 DAYS OF TREATMENT -

AGAIN, I AM ASSUMING THAT THE PATIENT IS A 150 lb. ADULT. THE PATIENT WILL SWALLOW THE FOLLOWING 3 TIMES A DAY, LET'S SAY AT 8:00 A.M., 2:00 P.M. AND 8:00 P.M. (a 6 hour interval in between).

DURING EACH OF THE THREE OCCASIONS THE PATIENT WILL SWALLOW -

A. ONE 900 mg. TABLET OF THIAZOLIDINE-4-CARBOXYLIC ACID

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B. ONE 1,000 mg. VITAMIN C TABLET (not timed release)

C. ONE MINERAL TABLET CONTAINING MAGNESIUM, ZINC AND MANGANESE.

D. AT EACH HOUR BETWEEN THESE 3 OCCASIONS, A 1,000 mg. TABLET OF VITAMIN C WILL BE SWALLOWED.

GENEROUS AMOUNTS OF WATER ARE TO BE SWALLOWED THOUGHOUT THE COURSE OF THE DAY, NOT SODA POP!

A RECAPITULATION - THE PROCEDURE TAKES 12 DAYS, 2 DAYS OF PREPARATION WITH VITAMIN C, 10,000 mg. EACH DAY, 20,000 mg. TOTAL. THE TREATMENT TAKES 10 DAYS. EACH DAY THE PATIENT (a 150 lb. adult) WILL CONSUME A TOTAL OF 2700 mg. OF THE ACID, 13,000 mg. OF VITAMIN C. 3 MINERAL TABLETS CONTAINING MAGNESIUM, ZINC AND MANGANESE; THIS MIGHT BE TOO MUCH; PERHAPS A ONE AND A HALF MINERAL TABLET WOULD SUFFICE; I DON'T WANT AN EXCESS TO CAUSE UNDUE TOXICITY; LIQUID 'IONIC' MINERALS MIGHT BE THE BEST TO USE.

PRESENTLY, THIAZOLIDINE-4-CARBOXYLIC ACID IS NOT COMMERCIALLY AVAILABLE TO THE CITIZENS OF THE UNITED STATES.

IN THE PAST IT HAS BEEN SOLD IN THE FOLLOWING COUNTRIES AS A LIVER 'CHOLERETIC'.

THE ACID'S COMMERCIAL NAME APPEARS IN PARENTHESIS; I ASSUME IT IS STILL AVAILABLE IN THESE COUNTRIES -

SWITZERLAND (Timonacic), SWITZERLAND (Heparegen), SWITZERLAND (Hepalidine), ITALY (Sulfile), SPAIN (Medialmine), SPAIN (Hepacitol), SPAIN (Livercrom)

This is all well and good, but what is a person to do if he or she cannot obtain this chemical from these foreign countries and does not know how to prepare chemically SARAH RATNER'S formula?

On December 1, 1997,

MRS. HELEN GUTIERREZ, 'THE HERB LADY'

of Portage, Indiana, and I thought of a way by which a person could generate Thiazolidine-4-carboxylic acid in his or her own body by simply swallowing the artificial sweetener, 'Equal', and the health food tablet, L-Cysteine, which can be purchased without a prescription.

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Equal is also know by the name 'NutraSweet'; the chemical name is 'Aspartame'.

Because of her phenomenal memory, Helen was able to remember from the first edition of Prescription for NUTRITIONAL HEALING by James F. Balch, M.D., that NutraSweet/Aspartame metabolizes into (changes into) formaldehyde; this information is not contained in the second edition of this book.

Here is how the passage appears on page 133 of the first edition:"Aspartame, the chemical name for NutraSweet, consists of three components: phenylalanine, aspartic acid, and methanol. Because NutraSweet contains methanol, a human specific and highly toxic poison, its safety should be examined.

Methanol is converted to formaldehyde and formic acid - two substances that have a toxic effect on the thymus gland....." Dr. Balch states on page 525 (2nd Edition): "T cells undergo maturation in the thymus gland..." Roberts' conclusion: people with HIV/AIDS should not use 'Equal'.

The following passage describes what happens in the human body when formaldehyde and L-Cysteine are 'mixed together'; this passage comes from the 'Journal of Nutrition', Volume 66, 1958, page 617; the authors did not realize (If my words prove true) that they had described the process by which the cure for cancer is generated:

"...Finally at physiological pH the spontaneous condensation of formaldehyde and cysteine to form thiazolidinecarboxylic acid is so rapid that when these two compounds are added to mitochondria the metabolism of cysteine is for all practical purposes entirely by way of the thiazolidine. The formation of thiazolidinecarboxylic acid 'in vivo' therefore provides a possible mechanism for the detoxification of exogenous and endogenous formaldehyde."

I have added vitamin C and the elements, magnesium & zinc & manganese and have designated the following as

'The Gutierrez/Roberts Procedure for the treatment of Cancer'.

THE PROCEDURE DEMANDS THAT TWO DAYS BEFORE THE TREATMENT COMMENCES THE PATIENT WILL HAVE SWALLOWED 10,000 mg. OF VITAMIN C (NOT TIMED RELEASE) EACH DAY. 10,000 mg. IS NOT TO BE SWALLOWED ALL AT ONCE, RATHER ONE 1,000 mg. VITAMIN C TABLET WILL BE SWALLOWED EVERY HOUR UNTIL 10 ARE CONSUMED BY THE END OF THE DAY. REGULAR VITAMIN C TABLETS ARE TO BE USED, NOT TIMED RELEASE. THE TOTAL OF THE VITAMIN C TABLETS SWALLOWED OVER TWO DAYS TIME WILL EQUAL 20,000 mg.

IF THE PATIENT DOES NOT SWALLOW VITAMIN C IN THE MANNER I DESCRIBE, I, JOHN S. ROBERTS AM NOT RESPONSIBLE, NOR IS MRS. HELEN GUTIERREZ REPONSIBLE, IF ANY HARM BEFALLS THAT PATIENT BECAUSE OF A FORMALDEHYDE OVERDOSE.

TO REPEAT, THE TREATMENT WILL ONLY BEGIN AFTER THE PATIENT HAS SWALLOWED A TOTAL OF 20,000 mg. OF VITAMIN C (NOT TIMED RELEASE).

 

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THE 10 DAYS OF TREATMENT -

THE TREATMENT FOR ADULTS IS AS FOLLOWS. THE PATIENT WILL SWALLOW THE FOLLOWING 3 TIMES A DAY, LET'S SAY AT 8:00 A.M., 2:00 P.M. AND 8:00 P.M. (a 6 hour interval in between).

TO REPEAT - ON THREE SEPARATE OCCASIONS DURING THE DAY, THE PATIENT WILL SWALLOW - (FOR A CHILD - ONE HALF THE AMOUNT, OR EVEN LESS) -

A. THREE L-CYSTEINE TABLETS (500 mg. each)

B. ONE MINERAL TABLET CONTAINING MAGNESIUM & ZINC & MANGANESE

C. ONE 1,000 mg. VITAMIN C TABLET

D. A LARGE GLASS OF WATER INTO WHICH HAD BEEN MIXED ONE HALF A KITCHEN MEASURING CUP OF 'EQUAL'; THIS IS THE EQUIVALENT OF 4 OUNCES OR 90 PACKETS OF 'EQUAL'

E. AT EACH HOUR BETWEEN THESE 3 OCCASIONS, A 1,000 mg. TABLET OF VITAMIN C WILL BE SWALLOWED.

GENEROUS AMOUNTS OF WATER ARE TO BE SWALLOWED THROUGHOUT THE COURSE OF THE DAY, NOT SODA POP!

A RECAPITULATION - THE PROCEDURE TAKES 12 DAYS, 2 DAYS OF PREPARATION WITH VITAMIN C, 10,000 mg. EACH DAY, 20,000 mg. TOTAL. THE TREATMENT TAKES 10 DAYS. EACH DAY THE PATIENT (an adult) WILL CONSUME A TOTAL OF 9 L-Cysteine tablets; 12 ounces of 'Equal' or the equivalent of 270 packets; thirteen 1,000 mg. vitamin C tablets; 3 mineral tablets containing magnesium & zinc & manganese (this might be too much, maybe one and a half tablets would suffice); perhaps 'ionic' minerals would be best.

Because it contains a 'Thiazolidine ring',

Thiazolidine-4-carboxylic acid is chemically related to

Penicillin. In other words, if I speak the truth, Cancer can be cured with a form of PENICILLIN.

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I began mailing out my cancer research in November, 1997. It was not until June 16, 1999, that I realized that the 'Vitamin C' aspect of the procedure had a medical name; it is called the 'Ascorbic Acid Flush'. The following passage is found on page 539 of the second edition of Prescription for NUTRITIONAL HEALING by James F. Balch, M.D. and Phyllis A. Balch, C.N.C.:

'Ascorbic Acid Flush'

"Because vitamin C (ascorbic acid) promotes the healing of wounds and protects the body from bacterial infection, allergens, and other pollutants, it is often beneficial to flush the body with ascorbic acid. This therapy can help treat chemical allergies and chemical poisoning, arsenic and radiation poisoning, influenza, and sprains, and it can help prevent other illnesses, including cancer and AIDS.

PROCEDURE FOR ADULTS

Place 1,000 milligrams of ascorbic acid in a cup of water or juice. To make this drink, use ascorbic acid in the form of either esterified vitamin C, such as Ester-C, or a buffered product, such as calcium ascorbate. Take every half hour, keeping track of how much has been taken, until diarrhea results. Count the number of teaspoons needed to produce diarrhea. Subtract 1 from this amount, and take the resulting ascorbic acid drink every four hours for one to two days. During therapy, make sure the stool retains a tapioca-like consistency. If it again becomes watery, decrease dosage as necessary. Repeat therapy once a month.

PROCEDURE FOR INFANTS AND CHILDREN

Place 250 milligrams of ascorbic acid in a cup of water or juice, using an esterified vitamin C product, such as Ester-C, or a buffered product, such as calcium ascorbate. Give to the child every hour until a stool of tapioca-like consistency is produced. If the child or infant does not produce this stool within 24 hours, increase dose to 500 milligrams every hour, and keep the child on this schedule for one or two days. Do not exceed 500 milligrams per hour. Children should be given treatment only under medical supervision."

I included this information in my June 27, 1999 letter addressed to three parties, namely:

Lake County Medical Society, Merrillville, Indiana

William Baldwin, Ph.D., Director, Northwest Center for Medical Education, Indiana University School of Medicine, Gary, Indiana

E. Ratcliffe Anderson, Jr., M.D., Executive Vice President, CEO, American Medical Association, Chicago, Illinois.

page 13

Among those to whom I mailed a copy are:

President Clinton, The White House,Washington, D.C.

Donna E. Shalala, Ph.D., Secretary of Health and Human Services, Washington, D.C.

Harold Varmus, M.D., Director, National Institutes of Health, Bethesda, Maryland

Richard Klausner, M.D., Director, National Cancer Institute, Bethesda, Maryland

Dr. Andrew V. Schally, Veterans Affairs Medical Center, New Orleans, Louisiana.(Should read 'Professor')

Is this the key to the cure for cancer? Thiazolidine-4-carboxylic acid is very HYROPHOBIC OR water repellent. Does this happen? The cancer cells absorb this acid and by so doing they concomitantly lose the ability to absorb water, and they consequently die. The healthy cells are not affected in a similar fashion. Is this a plausible explanation?

Don't forget, the Lethal Dosage amount for this acid is 400 mg/kg. whereas the Lethal Dosage amount for Tylenol is 338 mg/kg. If my words prove true, CANCER CAN BE CURED WITH A CHEMICAL COMPOUND THAT IS LESS TOXIC THAN ONE OF THE WORLD'S MOST POPULAR PAIN RELIEVERS - TYLENOL.

HIV/AIDS TROUBLES?

Because of my efforts (see Post Script) both the National Institutes of Health (NIH) and the Centers for Disease Control (CDC) have acknowledged that HIV, the virus which causes AIDS, can be inactivated in the test tube by the chemical compound, ACETALDEHYDE.

The chemicals which can inactivate HIV are 'few and far between'.

As the authors Peter S. Arno, Ph.D. and Karyn L. Feiden state on page 17 of, AGAINST THE ODDS - The Story of Aids Drug Development, Politics & Profits:

"Between 1987 and 1991 the National Cancer Institute tested 40,000 chemical compounds at facilities in Frederick, Maryland, and Birmingham, Alabama, to see if any could disable the AIDS virus. Despite the odds against finding a breakthrough drug, researchers continue to screen for compounds that can inhibit HIV at each step in the infection process: when it binds to the CD4 molecule; when it penetrates the helper T cell; when it transcribes its genetic code inside; and when it replicates. A more promising direction for future research is targeted drug development - that is , designing an effective drug based on the known biological structure of HIV."

However, there is an acid, L-2-Methylthiazolidine-4-carboxylic acid

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(L-MTCA), which is composed of L-Cysteine (one half) and ACETALDEHYDE (one half).

Years ago (1968-1970) L-MTCA was used as a 'cough inhibitor'.

L-MTCA is chemically simple to make, however it could be dangerous because acetaldehyde is flammable and could explode. The following passage is from the same 'Journal of Nutrition' which I cited previously; that citation described how 'thiazolidinecarboxylic acid' was formed in the body; which in my opinion, is the cure for cancer; the following citation, from page 610 of Volume 66, 1958, describes the process of formulating an acid which might prove to be very, very effective in inactivating HIV, the virus which causes AIDS -

"L-2-Methylthiazolidine-4-carboxylic acid was synthesized by a modification of the procedure described by Cook and Heilbron (THE CHEMISTRY OF PENICILLIN). Six grams of L-cysteine were dissolved in 15 ml of hot water and the pH of the solution was adjusted to 2.5 with hydrochloric acid. Five milliliters of freshly distilled acetaldehyde were added and the reaction mixture was allowed to stand at room temperature for several hours. The solution was then concentrated 'in vacuo' to a heavy syrup. The product was precipitated by the addition of absolute ethanol and collected on a sintered glass funnel. The yield, after recrystallization from 95% ethanol, was 2.6 gm. The melting point was 162-163 degrees, in agreement with the value reported by Cook and Heilbron."

It is my assumption that L-MTCA might be an effective ANTI-HIV agent because of its acetaldehyde content (one half).

Acetaldehyde is extremely toxic.

However, THE MERCK INDEX reveals the following about LETHAL DOSAGE (LD) amounts; 'LD50' means that 50% of the test animals died:

Acetaldehyde - LD50 orally in rats: 1930 mg/kg

Formaldehyde - LD50 (data not given as to whether it is rats or mice): 800 mg/kg

Thiazolidine-4-carboxylic acid - LD50 orally in mice: 400 mg/kg.

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Tylenol - LD50 orally in mice: 338 mg/kg.

THE LOWER THE AMOUNT, THE GREATER THE TOXICITY.

However, as far as acetaldehyde is concerned, The epoch research of Dr. Herbert Sprince discovered that a nutrient which can be purchased in any health food store, N-Acetyl Cysteine (NAC), afforded laboratory rats 100% PROTECTION AGAINST A LETHAL DOSE OF ACETALDEHYDE..

Consequently, the following procedure will also include NAC as an anti-acetaldehyde buffering agent.

Before I describe the procedure, let me cite two more facts about NAC -

1. NAC is the only substance known which can alleviate a Tylenol overdose.

2. Cigarette smokers could benefit from NAC; acetaldehyde is a toxic byproduct of cigarette smoking.

The Treatment for HIV/AIDS

Chemical abstract 77242v (refer to Chemical Abstracts, Volume 73, 1970) states that the Lethal Dosage amount of L-MTCA for mice is 300-400 mg/kg.

This falls in the range of Tylenol - 338 mg/kg. If my words prove true, HIV/AIDS CAN BE SUCCESFULLY TREATED WITH A CHEMICAL COMPOUND WHICH IS NOT ANY MORE TOXIC THAN ONE OF THE WORLD'S MOST POPULAR PAIN RELIEVERS - TYLENOL. IN MY OPINION, IT IS THE TOXICITY OF ACETALDEHYDE WHICH WILL INACTIVATE HIV, THE VIRUS WHICH CAUSES AIDS.

Let's follow the example I gave for a cancer patient. For adults, let's start out by administering 40 mg/kg. For children, let's start out by administering 20 mg/kg.

page 16

Let's suppose the adult patient weighs 150 lbs. (68 kg.) -refer back to the cancer example - Everyday, at 8:00 A.M., 2:00 P.M. and 8:00 P.M., the patient will swallow 900 mg. of L-MTCA. The daily amount will thus total 2700 mg. (40mg x 68 kg equals 2720 mg.). In addition, at 8:00 A.M. & 2:00 P.M. & 8:00 P.M. the patient will swallow a 600 mg. tablet of NAC.

HOPEFULLY, THE PATIENT WILL SOON SEE HIS OR HER 'T-CELL' COUNT BEGIN TO RISE.

If people cannot chemically prepare this acid, it is my suggestion that they stay safely in their homes, do not drive a vehicle, and periodically swallow some L-Cysteine tablets and drink some alcohol. The alcohol will metabolize into acetaldehyde which will combine with the L-Cysteine to form L-MTCA. Also, swallow some NAC.

Since it contains a 'Thiazolidine ring', L-MTCA is also related to PENICILLIN.

DRINKING PROBLEMS?

During the course of my research I have discovered some facts about alcohol and nutrition which are generally not well known by the public. In fact, I would be willing to bet that not one person in a million who drinks alcohol is aware of these facts!

After you read them, I hope you will agree with me that the Surgeon General of the United States of America should order manufacturers of alcoholic beverages to print a third warning on all their containers of alcoholic beverages; that warning should be:

(3) PROPER METABOLISM OF ALCOHOL REQUIRES THE INGESTION OF ABOVE AVERAGE AMOUNTS OF ZINC, VITAMIN B-6 AND VITAMIN C.

Here are the facts which I have found in various reference sources; the emphasis is mine.

1. "6. Cut way back on beer and other alcoholic drinks. They wipe out zinc and B-6. Beer also encourages hormones that promote prostate growth." Dr. Bruce Miller, The Nutrition Guarantee, page 374.

2.. Is anyone in the world, except the Encyclopaedia Britannica and me aware of the following fact? -

"As absorbed alcohol is passed through the liver by the circulating blood it is acted upon by ADH (alcohol

page 17

dehydrogenase), a zinc-containing enzyme found chiefly in the liver cells..." Encyclopaedia Britannica - Macropaedia, Volume 1, page 438, 1974 Edition.

3."It would be a good idea, too, to add vitamin B-6 or pyridoxine to the components of this antiacetaldehyde nutritional packet. Since pyridoxine plays a part in the metabolic conversion of amino acids, even a marginal deficiency in this vitamin might slow down the conversion of sulfur-containing amino acids." THE COMPLETE BOOK OF VITAMINS by the Staff of Prevention Magazine, page746.

ALCOHOL METABOLIZES (CHANGES) INTO ACETALDEHYDE WHICH IS HIGHLY POISONOUS. - John S. Roberts

4. From 'The INTERNET': "Pyridoxal phosphate (vitamin B-6) is normallly protected from degradation by its binding to the amine group of lysine residues of proteins, including serum proteins and hemaglobin. Acetaldehyde may, by binding preferentially to these residues, displace pyridoxal phosphate and result in its increased destruction, and in abnormally low blood levels of this co-enzyme."

From Let's Get Well by Adelle Davis: "Pancreatitis. the pancreas, a long, slender organ that secretes insulin and digestive enzymes, lies below and to the left of the stomach. An inflammation of this organ, or pancreatitis, has been produced by diets deficient in vitamin B-6,..." page 157

My (John S. Roberts) conclusion: In other words, if you are an habitual drinker of alcohol you better include in your diet an above average amount of vitamin B-6; if you don't, you could develop pancreatitis;

the reason for this is that the poisonous part of alcohol, acetaldehyde, unnaturally depletes the body's supply of vitamin vitamin B-6; without this vitamin the pancreas will tend to swell. As far as I can determine, I, John S. Roberts, am the first person in the history of medicine, to see this relationship.

page 18.

5. "...the liver depends on vitamin C to produce an enzyme - alcohol dehydrogenase - that helps usher alcohol out of the bloodstream. The less vitamin C there is, the longer the body stays polluted." THE COMPLETE BOOK OF VITAMINS by the Staff of Prevention Magazine, page 302.

6. The following fact about vitamin B-6 (Pyridoxine) is found on page 26 of the 'Mason natural Nutrition Guide' (www.masonvitamins.com): "Pyridoxine is water soluble and is excreted by the body within 8 hours of intake. It is necessary for the reproduction of antibodies and red blood cells. It is believed to be important in the proper absorption of another B vitamin, B-12. Some doctors suggest higher doses for pregnant or nursing women..."

7. I can't locate the source for this, but I am going to include it anyway; it comes from a page titled, "ALCOHOLISM", and is subtitled in bold face type, 'Building with Bs':

"Aside from a thiamin deficiency, excessive drinking can also cause a deficiency of vitamin B-6, a nutrient needed to transmit nerve impulses. Doctors report that even a mild deficiency of vitamin B-6 alters brain waves and that a severe deficiency can cause convulsive seizures.

'Pyridoxine, or vitamin B-6, seems to be destroyed by alcohol' says Dr. Halsted. Over 50 percent of those who drink excessively seem to have deficiencies. Eating a well-balanced diet that includes the Daily Value of vitamin B-6 -two milligrams- can correct the problem, says Dr. Halsted, but only if no further alcohol is consumed. Good food sources of vitamin B-6 include potatoes, bananas, chick-peas, prune juice and chicken breast."

Do 'problem drinkers' eat a nutritional diet? I wish to ask this question in conluding this segment.

If they don't, could we say then that they are abusing their body with ALCOHOL?

I hope the following information might prove useful for anyone troubled by Lou Gehrig's Disease and Macular Degeneration, a cause of blindness.

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Lou Gehrig's Disease (ALS) Amyotrophic Lateral Sclerosis - THE MEDICAL ADVISOR, Time-Life Books, 1996, states on page 554:

"Though the cause of ALS is unknown, genetic inheritence plays a role in 5 to 10 percent of cases. Some researchers believe that so-called familial ALS (that is, inherited ALS) is caused by a defective gene that prevents the body from producing a normal amount of an enzyme called superoxide dismutase (SOD). This enzyme helps neutralize free radicals, highly reactive oxygen molecules produced during metabolism and capable of damaging body tissues. Researchers speculate that defects in protective enzymes may also account for noninherited ALS, and that environmental toxins may be a factor."

On page 555 THE MEDICAL ADVISOR goes on to say:

"Although no treatment slows or halts the progression of the disease, various drugs and devices are available to help control symptoms and make living with ALS easier."

"Tests indicate that some neuromuscular symptoms may be relieved by 200 to 1,200 IU of vitamin E (underline) with thiamine (vitamin B-1) each day. Some evidence suggest that supplements of coenzyme Q10, a protein catalyst, may slow nerve-tissue atrophy that comes with ALS. In addition, the amino acids leucine, isoleucine, and valine may help ALS patients maintain muscle strength and prolong walking ability."

Recently I became aware of these words relative to 'Barleygreen' which is not mentioned in THE MEDICAL ADVISOR; a seven ounce jar costing $38.00 can be ordered from Health Resources, P.O. Box 3623, Hueytown, Alabama 35023 (I, John S. Roberts, am in no way associated with this enterprise.) -

"What really sets this powdered barley juice apart from other food supplements is the presence of many usable enzymes and chlorophyll. The anti-aging enzyme 'superoxide dismutase (SOD)' is one of these. Dr. Richard Cutler, a biophysicist at the National Institute of Aging has shown that life-span is directly proportional to the amount of SOD contained in the cells. Anti-oxidants such as SOD protect the body from toxic free radicals."

I, John S. Roberts, wish to ask this question? - Could Barleygreen retard, or at least slow down, the damage done to spinal neurons and thus lessen the severity of Lou Gehrig's Disease?

Retinal Damage from Macular Degeneration -

I know a lady who is suffering from this and visited three different eye specialists who told her that nothing can be done about it. However, THE MEDICAL ADVISOR states on pages 320 and 952 and 571:

page 20

"Ginkgo (Ginkgo Biloba), extracts have been used to stem deteriorating vision in patients by maintaining adequate blood flow to the retina..."

"Herbalists believe that ginkgo may interfere with the development of blood clots and the processes that constrict bronchial tubes during an asthma attack. In addition it may help reduce retinal damage from macular degeneration, a cause of blindness particularly threatening for diabetics. And it may help reverse deafness caused by reduced blood flow to the nerves involved in hearing."

"Many older people exhibit deficiencies in zinc, which normally appears in high concentrations in the retina, particularly the macula. Ask your doctor about taking a zinc supplement to help protect the macula from damage..."

HAVE I, JOHN STACY ROBERTS, REALLY AND TRULY DISCOVERED THE CURE FOR CANCER?

If I have, the discovery came about in a most unusual fashion ; I am going to write this in the third person -

In November, 1991, John S. Roberts, employed since 1968 by the Lake Ridge School System of Gary, Indiana, as a school librarian, was inspired to do HIV/AIDS research because he was saddened to learn that the basketball superstar, 'Magic' Johnson, had been infected with HIV, the virus which causes Aids.

During the course of his research, Roberts had learned that HIV could be inactivated in the test tube by the chemical compound, acetaldehyde; in 1995 this information was provided to Roberts by the Centers for Disease Control (CDC) and to his Congressman, Peter J. Visclosky, by the National Institutes of Health (NIH).

Also, during this time, Roberts had been immersing himself in the research of Dr. Herbert Sprince and his associates.

Roberts was intrigued by the fact that Dr. Sprince had found three substances which provided 100% protection (in laboratory rats) against LETHAL DOSES of acetaldehyde; they are NAC, L-Cysteic acid.H20, and the combination of L-Ascorbic acid & L-Cysteine FB & Thiamin.HCL.

Roberts was trying to find a means 'to buffer' against acetaldehyde's toxicity if it were discovered that acetaldehyde could be used to inactivate HIV in the human body.

By mere happenstance, Roberts noted that in one of his studies Dr. Sprince stated something to the effect that vitamin C (L-Ascorbic acid) provided protection against the toxicity of formaldehyde. However, Roberts did not pay too much attention to this because his primary focus was upon acetaldehyde.

On August 31, 1997, while rereading Dr. Sprince's research, Roberts became aware of this passage: ".....Chemically, L-cysteine by way of its (-SH) group complexes with acetaldehyde to form L-2-methylthiazolidine-4-carboxylic acid (L-MTCA) by way of an intermediary hemiacetal or Schiff base, ....."

In his research Roberts stated: "Although it is non-toxic to the body, could L-MTCA still somehow be toxic to HIV thereby inactivating it? If this be so, then L-MTCA will prove to be 'the Magic Bullet', and not acetaldehyde, as far as the cure for AIDS is concerned." Roberts searched various references books to find a citation to L-MTCA.

page 21

On Friday, September 5, 1997, Roberts presented to Mrs. Mary Ann Nickoloff a science teacher at Lake Ridge Middle School, Gary, Indiana, 20 pages of his research.

Mrs. Nickoloff and Roberts had been collaborating in doing HIV/AIDS research.

On Monday, September 8, 1997, Roberts showed to Mrs. Nickoloff a chemical listed in the Handbook of Chemistry and Physics, No. 13820, which contained the words, "5-Thiazol carboxylic acid, 4-methyl-2-sulfanilamide"; he wondered if this might be the acid to which Dr. Sprince referred.

Mrs. Nickoloff thought it would be a good idea to fax the information over to the regional campuses of Indiana and Purdue University and get their opinion. She made the necessary calls and left messages since the parties she needed to talk to were not in at the time.

Roberts told Mrs. Nickoloff that he was going over to Indiana University after the school day had ended. He was going to show his data to a Professor of Pharmacology who he had talked to several times before; in 1993, this professor, Professor Subbiah Sivam, had clued Roberts in to the meaning of the biological term, 'half-life'.

Professor Sivam told Roberts that he was wrong about No. 13820; however, because he could not locate L-MTCA, he recommended that Roberts speak to somebody in the chemistry department.

At 4:30 P.M. Roberts showed L-MTCA to Mrs. Linda Wozniewski, a lady whose specialty is inorganic chemistry. She tried to locate it in THE MERCK INDEX and chemical supply sources such as IGN and the ALDRICH CATALOG. Because she could not find it, she recommended that Roberts talk with someone whose specialty was organic chemistry.

Later that evening Roberts called Mrs. Nickoloff and told her that he hoped to visit, the next day, an Associate Professor of Organic Chemistry whose office hours, he noted, would be 2:00 to 4:00 P.M., perfect for Mrs. Nickoloff and Roberts because their school day ended at 2:45 P.M., and it took only a few minutes to drive to I.U. Roberts invited Mrs. Nickoloff to come with him if he could make an appointment with the professor, and she accepted.

Tuesday, September 9, about 8:15 A.M. Roberts called Professor Atilla Tuncay, and he gladly accepted to see Mrs. Nickoloff and Roberts; they arrived at his office about 3:00 P.M. The meeting lasted for about forty five minutes.

The emphasis is Roberts'.

Professor Tuncay could not locate L-2-Methylthiazolidine-4-carboxylic acid anywhere, but he did find a chemical listed in THE MERCK INDEX which was made out of L-cysteine and formaldehyde; here is that chemical as it is described in THE MERCK INDEX (I like to refer to it as 'The Chemical Cousin' of L-MTCA):

page 22

"9375. Timonacic. 4-Thiazolidinecarboxylic acid; ATC; norgamen; thioproline; NSC 25855; Detoxepa; Hepalidine; Heparegene; Thiobiline; Tiazolidin. C4/H7/NO2/S; mol. wt. 133.18. C 36.07%, H 5.30%, N 10.52%, O 24.03%, S 24.08%. Prepd from DL- or L-cysteine and formaldehyde. Prepn of l-form: Ratner, Clarke, J. Am Chem. Chem. Soc. 59, 200 (1937); of dl- and l-forms: Werner et al., Helv. Chim. Acta 30, 432 (1947); Fr.. pat. M3184 (1965 to Sogespar S.A.), C.A. 63, 12980h (1965). Proton magnetic resonance and conformation: Martin, Mathur, J. Am. Chem. Soc. 87, 1065 (1965). Series of articles on pharmacology and toxicology: Gazz. Med. Ital. 131, 251-286 (1972). Treatment of cancer through induced reverse transformation: A. Brugarolas, M. Gosalvez, Lancet 1, 68 (1980).

dl- Form, crystals, mp 195 degrees. LD50 orally in mice: 400 mg/kg, Bertrand, Piton, Gazz. Med. Ital. 131, 265 (1972). l-Form, crystals from water, dec 196-197 degrees. Readily sol in hot water, acid, alkali; sparingly sol in cold water; practically insol in alcohol.

Therap Cat: Choleretic." The entry ends here.

Professor Tuncay showed this entry to both Mrs. Nickoloff and Roberts.

Roberts noticed that the entry said something about 'cancer' but did not pay too much attention to it because he did not want to be distracted from his HIV/AIDS research, and moreover, had a sense of trepidation about doing cancer research because of his lack of knowledge of biochemistry.

It was fortunate that Mrs. Nickoloff had attended the meeting with Roberts because she stayed afterward (Roberts had driven straight home.) and made copies of two of the articles cited by the 9375. Timonacic. entry and presented them to him the next morning. One of them is titled, 'Proton magnetic resonance and conformation' and the other is titled, 'Treatment of cancer through induced reverse transformation'.

Left on his own, Roberts might never have looked up this cancer article.

However, the more he read the article, the more intrigued he became about the passages which you see referred to on page 5 of this report. Don't forget, they are found in one of the world's foremost and prestigious medical journals, 'The Lancet', January 12, 1980, pages 68 to 70.

Although the article itself did not reveal it, Roberts subsequently discovered that the acid used in this cancer clinical trial is composed of L-Cysteine (one half) and formaldehyde (one half). It's as simple as that!

Roberts remembered Dr. Sprince's findings about the protective power of vitamin C against lethal doses of formaldehyde.

Thus, Roberts reasoned, if cancer patients swallowed 'mega-doses' of vitamin C they could, at the same time, swallow 'mega-doses' of the acid. It's as simple as that! - if Roberts speaks the truth -

The Cure for Cancer.

.page 23

The Cure for HIV/AIDS?

Is this a possibility? Thanks to one of Dr. Sprince's bibliographies, I eventually located a description of L-MTCA in Chemical Abstracts, Volume 73, 1970, page 77242:"77242v 2-Methylthiazolidine-4-carboxylic acid as cough inhibitor. Bertrand, Francois R. (Sogespar S.A.) Ger. Offen. 1,965,343 (Cl. C 07d), 23 Jul 1970. Fr. Appl. 31 Dec 1968;16 pp. The title compd. (I) and its Me ester (II) and amide (III) were prepd., and formulations of tablets, suppositories, solns., and suspensions contg. I as active substance were reported. Thus, reaction of cysteine with AcH at 15-20 degrees gave 84% I. Reaction of 100 g I with 11. MeOh in the presence of HCl gave 15 g II. Reaction of 100g II. HCL in MeOH with NH3 at 0-10 degrees gave 60 g III. I, II, and III had 300-400 mg/kg s.c. LD50 in mice. I, II, and III reduced the viscosity of mucus by 35-65% after 15 min." The abstract ends here.

This compound effectively "reduced the viscosity of mucus by 35-65% after 15 min.".

Since it contains a 'Thiazolidine ring', this compound is chemically related to PENICILLIN.

One half of this compound is composed of acetaldehyde.

Both the NIH and CDC have acknowledged that HIV, the virus which causes Aids, can be inactivated in the test tube by acetaldehyde.

It might be a good idea to use NAC (N-Acetyl Cysteine) in conjunction with this compound because the EPOCH RESEARCH OF Dr. HERBERT SPRINCE has shown that NAC affords 100% protection against a lethal dose of acetaldehyde; the test subjects were laboratory rats.

EVERY DRINKER AND EVERY SMOKER IN THE WORLD SHOULD BECOME AWARE OF THIS MONUMENTAL AND EPOCH RESEARCH -

"Protective Action of Ascorbic Acid and Sulfur Compounds against Acetaldehyde Toxicity: Implications in Alcoholism and Smoking", and the authors are Herbert Sprince, Clarence M. Parker, George G. Smith and Leon J. Gonzales.

I, John Stacy Roberts, am the author of these pages. I was born on October 24, 1936, in Gary, Indiana. I graduated from Horace Mann, Gary, in 1954, and Indiana University, Bloomington, Indiana, in 1962, B.S. in Education, and in 1968, M.L.S. in Library Science.

From 1955 - 1957 I served in and was honorably discharged from the United States Army. From 1968 - 1999 my career was with the Lake Ridge School System of Gary, Indiana; I served as middle school librarian and also, from 1992, as Library Coordinator. I am presently retired.

www.jsr1936.com / e-mail address: jsr1936@jsr1936.com

Post Office Box H, Hobart, Indiana 46342, Telephone: (219) 763-1933

Host of 'Alternative Health Choices', a Portage, Indiana, Cable Television Program, Wednesday Evening, 5:30 P.M., Channel 4.

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I would like to express my appreciation to the following people for their contributions to my research efforts; the listing is alphabetical -

Mr. Mike Fernandez, Mrs. Helen Gutierrez, Mrs. Mary Ann Nickoloff, Mrs. Ricarda Ortiz, Professor Subbiah Sivam, Professor Atilla Tuncay and Mrs. Linda Wozniewski; and last, but not least, my wife, Margaret.

Post Script:

Beginning in November, 1997, and throughout 1998, and from January, 1999, until June 27, 1999, I have been alerting Federal Health Officials in the Washington, D.C. area about my cancer, HIV/AIDS, and alcohol abuse research; the cumulative weight of my individual letters now totals 8 pounds (since November, 1997); thus far, I have never received a definitive response from anyone. First, something about HIV/AIDS -

Going as far back as January, 1993, I started to suggest to the National Institutes of Health (NIH) that I thought acetaldehyde might be an effective anti-HIV agent.

These responses to letters of mine and Congressman Peter J. Visclosky emanated from the offices of the NIH throughout 1993 -

A January 26, 1993 letter to me - "...The molecules you suggest (j.s.r. - acetaldehyde) are normal metabolites formed during normal body functioning, and would have no effect on HIV or AIDS..."

A March 24, 1993 letter to me - "...However, acetaldehyde is a normal metabolite of the human body and will have no effect on HIV infection."

A June 18, 1993 letter to Congressman Visclosky - "...Acetaldehyde, however, only has been associated with some of the side effects of DTC, e.g., fatigue and nausea.

As there is currently no scientific basis to believe that acetaldehyde has any anti-HIV activity, the NIH is not pursuing the development or preclinical evaluation of this agent. I hope you will find this information useful in addressing Mr. Roberts request for assistance."

A September 22, 1993 letter to me - "...Acetaldehyde is a normal metabolite of the human body that would not significantly hinder HIV infection."

A November 1, 1993 letter to me - "...To date, the NIH has not identified any compelling data or a convincing rationale to pursue acetaldehyde as an anti-HIV agent..."

However, I kept suggesting to the NIH that I thought acetaldehyde might prove to be the key to the cure of HIV/AIDS.

Eventually, the NIH reevaluated acetaldehyde and stated in an August 9, 1995 letter to Congressman Visclosky:

"The fact that acetaldehyde inactivates the human immunodeficiency virus (HIV) in test tube experiments does not necessarily make it a good candidate for anti-HIV therapy in humans....."

page 25

In other words, throughout 1993, I was right in my estimation of acetaldehyde's power over HIV, and the National Institutes of Health (NIH) was wrong. It's as simple as that!

Coincidentally, on February 1,1995, the Centers for Disease Control (CDC) wrote to me a letter in which they stated:

"Below are the responses to your specific questions regarding acetaldehyde:

1. 'Does acetaldehyde destroy HIV in the test tube?'

All the aldehydes are capable of inactivating HIV; however, their actual effectiveness depends on the concentration used.

2. 'Was acetaldehyde on that list of 40,000 compounds tested at Frederick, Maryland and Birmingham, Alabama to see if any could disable HIV?'

Centers for Disease Control and Prevention (CDC) officials are unaware of a study to look at '40,000 compounds' to inactivate HIV. However, within the National Institutes of Health (NIH) a group of researchers are examining various chemicals for therapeutic use, although not inactivation."

I (John S. Roberts) hope the Director of the National Aids Policy Office ('The Aids Czar') proceeds expeditiously to test whether L-MTCA might prove to be an effective anti-HIV agent.

L-MTCA should be fairly safe to use; in the past it was used as a 'cough inhibitor'.

To repeat, L-MTCA is composed solely of L-Cysteine (one half) and acetaldehyde (one half).

I wish to repeat this fact - HIV can be inactivated in the test tube by acetaldehyde! Both the NIH and CDC have said so. Now, about alcohol -

I hope the Surgeon General of the United States of America immediately orders manufacturers of alcoholic beverages to update their warning labels on all their containers to read:

GOVERNMENT WARNING: (1) ACCORDING TO THE SURGEON GENERAL, WOMEN SHOULD NOT DRINK ALCOHOLIC BEVERAGES DURING PREGNANCY BECAUSE OF THE RISK OF BIRTH DEFECTS. (2) CONSUMPTION OF ALCOHOLIC BEVERAGES IMPAIRS YOUR ABILITY TO DRIVE A CAR OR OPERATE MACHINERY, AND MAY CAUSE HEALTH PROBLEMS. (3) PROPER METABOLISM OF ALCOHOL REQUIRES THE INGESTION OF ABOVE AVERAGE AMOUNTS OF ZINC, VITAMIN B-6 AND VITAMIN C.

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If I were Surgeon General of the United States of America and failed to issue such an order, I would consider myself

DERELICT IN MY DUTY. Now about cancer -

My fellow citizen -

You have been able to see for yourself that an acid is described on 'MedLine' as being "anti-cancer".

My fellow citizen -

You have been able to see for yourself that phenomenal anti-cancer results were achieved 20 years ago when this acid, by itself, was administered to human beings (In Spain in the latter half of 1979).

My fellow citizen -

It is my hope that you will ask your National Representative and your two National Senators to urge the Director of the National Institutes of Health to repeat a clinical trial which showed, 20 years ago, such promising anti-cancer results and was reported in 'The Lancet', one of the world's foremost and prestigious medical journals; the specific issue is January 12, 1980, pages 68-70.

Only this time, I hope the trial would be repeated in the manner I have described on these pages.

If I speak the truth, The Cure for Cancer, is 'Mega-Doses' of Thiazolidine-4-carboxylic acid and vitamin C and 'above average' amounts of magnesium, zinc and manganese.

THIS ACID AND THIS VITAMIN AND THESE ELEMENTS (IN THE FORM OF A MINERAL SUPPLEMENT) ARE TO BE SWALLOWED.

The procedure which I have described on these pages which utilized 'Equal' and L-Cysteine and vitamin C and magnesium and zinc and manganese has been tried two times and success was engendered on each occasion.

In early December, 1997, within a week, Mrs. Helen Gutierrez cured her brother of esophageal cancer using this procedure. First, Helen told her brother to swallow 'mega-doses' of vitamin C for two days.

I saw a television interview in which an 'Equal' company official stated that "97 packets of 'Equal' a day was 'too much'." 'Equal' metabolizes into formaldehyde which is a deadly poison.

During the first week of December, 1997, Mrs. Helen Gutierrez administered, everyday, to her brother, the equivalent of 600 packets of 'Equal'; she did this for five days; her brother experienced no ill effects whatsoever; his only complaint was that the mixture was, "awfully sweet".

page 27

I am not sure whether Helen's brother swallowed any minerals, but at this time I would like to cite the following passages which would seem to indicate the need for magnesium, zinc and manganese -

'Proceedings of the National Academy of Sciences', Volume 88 (1991), page 4848, states: "Recently, a number of newly discovered antitumor antibiotics..." "...NMR and x-ray crystallographic studies showed that chromomycin, containing a disaccharide and trisaccharide unit, is preorganized into a dimer (mediated by a magnesium ion) and bound to the minor groove of DNA in a distorted A-DNA conformation..."

Unique Identifier 88098591 of 'Medline', 'Distribution of electric charges in 2 substances inducing tumor cell regression', states: "The charge distribution of anti-cancer molecules 4-thiazolidine-carboxylic acid and 2-amino-2-thiazoline hydrochloride was calculated with a CNDO/2 semiempiral quantum mechanic method. The activity seems to be related with the formation of Zn2plus (zinc) and Mn2plus (manganese) ions. Both molecules show local isosterism, origin of their chelating properties."

Thanks to Mrs. Ricarda (Ricky) Ortiz, 'Laredo Health & Organic Foods', I met Mr. Mike Fernandez of Laredo, Texas.

Mike was born of March 24, 1938; when he turned 50 he made it a practice to go to his doctor for regular physical examinations.

In the Fall of 1998, Mike became concerned when his 'PSA' count reached 5.9.

The PSA count is an indicator of potential prostate cancer in men.

The AMERICAN CANCER SOCIETY booklet, Prostate cancer, states on page 7:

"Prostate-Specific Antigen Blood Test (PSA)

The American Cancer Society recommends that this blood test to measure PSA (a protein which is made by prostate cells) be offered annually by health care providers to men 50 and older with a life expectancy of at least 10 years, and to younger men with high prostate cancer risk. At this time, the health care provider should also discuss the risks and benefits of early detection and treatment of prostate cancer.

PSA blood test results are reported as 'nanograms per milliliter' or 'ng/ml'. Results under 4 ng/ml are usually considered normal. Results over 10 ng/ml are high and values between 4 and 10 are considered 'borderline'. The higher the PSA, the more likely the presence of prostate cancer."

Mike had two subsequent sonograms and two subsequent biopsies in 1999 and was told on his birthday, March 24, that he did, indeed, have prostate cancer; it was labelled, 'non-aggressive'.

The same AMERICAN CANCER SOCIETY booklet states on page 15:

"CHEMOTHERAPY

Chemotherapy is used for patients whose prostate cancer has spread outside of the prostate gland and for whom hormone therapy has failed. It has shown only limited success in treating advanced disease, but it may slow tumor

page 28

growth and reduce pain. Chemotherapy is not effective against early prostate cancer." (My emphasis)

I told Mike about 'The Gutierrez/Roberts Procedure', and he readily agreed to try it. In late April and early May of 1999, by swallowing 'Mega-doses' of 'Equal' and L-Cysteine and vitamin C and 'above average' amounts of a mineral supplement, Mike saw his PSA plummet to '0.6'; the reading was reported on May 14, 1999.

On June 25, Mike called me and told me that his 'PSA' had fallen even further, to '0.2'.

Previously I had written a letter, dated May 31, 1999, and titled, 'THE MIRACLE OF LAREDO'. I included in that letter much of the information which you have read on these pages; the letter is 18 pages long.

The 'MIRACLE' refers to the fact that Mike's PSA had plummeted to 0.6; it had once been as high as 5.9; his prostate cancer had been confirmed by two sonograms and two biopsies; supposedly, early prostate cancer is not susceptible to chemotherapy.

Is the experience of Mr. Mike Fernandez of Laredo, Texas, the first in the history of the world wherein early prostate cancer has responded to chemotherapeutical treatment?

Mike and Helen's brother subjected themselves to a simple treatment for cancer - 'Equal' and L-Cysteine and vitamin C and magnesium, zinc and manganese (Helen's brother might not have swallowed a mineral supplement.).

The experiences of Mike and Helen's brother demonstrate that vitamin C affords phenomenal protection against the toxicity of formaldehyde; an 'Equal' (which metabolizes into formaldehyde) company official stated in a television interview that 97 packets a day was "too much". Mike took almost 3 times this amount - 270 packets a day !, and Helen's brother took almost 6 times this amount - 600 packets a day !

However, this is not the best way to administer a cure for cancer because as Dr. Balch points out on page 9 of Prescription for NUTRITIONAL HEALING , Second Edition: (aspartame is 'Equal')

"No one disputes that aspartame should be avoided by people with phenlyketonuria (PKU). People with PKU lack the enzyme needed to convert phenylalanine into tyrosine, another amino acid. As a result, high concentrations of phenylalanine accumulate and can cause brain damage. It should be noted that a number of people who have disorders other than PKU - people with iron deficiencies and kidney disease, for instance - may also be prone to high levels of this amino acid. For such people, the consumption of aspartame may increase the risk of toxicity."

A better treatment could be brought about if 'Tac' were available in pill form.

Isn't this what the world has been looking and waiting for?

A simple cure for Cancer!

www.jsr1936.com

page 29

If I, John Stacy Roberts have indeed discovered the cure for cancer, credit is due to the individual who first formulated Thiazolidine-4-carboxylic acid, and that person is Sarah Ratner.

The following information is found in the 'Journal of the American Chemical Society', Volume 59, January, 1937, pages 200 and 206: On October 31, 1936, the Faculty of Pure Science of Columbia University, New York City, received a report "from a dissertation submitted by Sarah Ratner in partial fulfillment of the requirements for the degree of Doctor of Philosophy..." Pages 200 to 206 contain the complete report.

Page 203 contains the passage wherein Sarah Ratner described the means by which she formulated Thiazolidine-4-carboxylic acid. Refer back to page 7 of this report to see how she did it.

Her subsequent career is described in NOTABLE TWENTIETH-CENTURY SCIENTISTS, Emily J. McMurray, Editor, Gale Research Inc., Detroit, Michigan, 1995, Volume 3, L-R, page 1653 -

"Sarah Ratner 1903- American biochemist

Sarah Ratner is a biochemist whose research has focused on amino acids, the subunits of protein molecules. Her use of nitrogen isotopes to study metabolism - the chemical processes by which energy is provided for the body - resulted in the discovery of argininosuccinic acid, a substance formed by a sequence of reactions that take place in the liver. Ratner's awards for her work include the Carl Neuberg Medal from the American Society of European Chemists in 1959.

Ratner was born in New York City on June 9, 1903, the daughter of Aaron and Hannah (Selzer) Ratner. She received her bachelor of arts degree from Cornell University before proceeding to Columbia University for graduate studies, where she received an M.A. in 1927. Ratner worked as an assistant in biochemistry in the College of Physicians and Surgeons of Columbia University until she received her Ph.D. in biochemistry from the university in 1937. Following her graduation she was appointed a resident fellow at the College of Physicians and Surgeons and rose to the positon of assistant professor. In 1946 she became an assistant professor of pharmacology at the New York University College of Medicine in New York City. Later, she became associated with the New York City Public Health Research Institute as an associate member of the division of nutrition and physiology and became a member of the department of biochemistry in 1957.

In her research Ratner used an isotope of nitrogen to study chemical reactions involving amino acids, particularly arginine. Isotopes are atoms of an element that have a different atomic mass than other atoms of the same element. Through her studies she discovered an intermediate molecule, called argininosuccinic acid, which forms when the amino acid citrulline is converted to arginine. Ratner determined that argininosuccinic acid plays an important role in the series of chemical reactions that occur in the liver and leads to the formation of urine. This sequence of reactions is known as the urea cycle. Urea, a product of protein metabolism, has a high nitrogen content and is excreted by mammals.

The American Chemical Society honored Ratner with the Garvan Medal in 1961, and in 1974 she was elected to the National Academy of Sciences. In addition, she received research grants from the National Institutes of Health (NIH) for over twenty years, and from 1978 to 1979 she was the institutes' Fogarty Scholar in Residence and served as a member of the advisory council. She has received honorary doctorates from the University of North Carolina-Chapel Hill, Northwestern University, and State University of New York at Stony Brook."

---Sketch by M.C. Nagel, Copy to Sarah Ratner @ Public Health Research Institute, New York City, New York

page 30

If I, John Stacy Roberts, speak the truth, Cancer can be Cured by swallowing 'mega-doses' of Thiazolidine-4-carboxylic acid ('Equal' and L-Cysteine) and vitamin C, and 'above average' amounts of magnesium, zinc and manganese.

If my words prove true, it is a tragedy that this cure is not being provided to mankind.

Copies of this report are being mailed to President Clinton, the Nobel Committee for Medicine, Professor Andrew V. Schally, Government and Health Officials and the parties I have named herein. j.s.r.